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Mephedrone is similar to three-CMC in framework. Only variation is wherever the methyl groups are placed. The worth for this certain specimen is R3, though mephedrone is R4.

The usage of the beta carbon during the amphetamine structure allows for the discovery of cathinones like 3 CMC by the use of kettone substitution. Two methyl substitutions are available in the three-CMC cathinone structure, a single for the phenyl rings and one in the nitrogen group.

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